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these very partial freaks of disease to visceral irritation, and in
that case it must be through the sympathetic nerves, just as we
might expect. He evidently had distinct and well-defined ideas
about these cases forty years ago. He correctly grouped them
together, and yet, apart from all other kinds of local palsies, such
as arise from injury of the spinal cord and nerve trunks, or
from lead. In 1849, M. Duchenne, of Boulogne, presented a
memoir to the Institute of France, entitled " Atropine muscvr
laire avec transformation graisseuse." In 1853, M. Cruveilhier
read Ins researches on this subject before the Academie de Mede-
cine, and so graphic was the delineation of this mysterious
malady, that progressive wasting palsy has been termed " Pro-
gressive Paralysis of Cruveilhier," or " Cruveilhier's Atrophy."
This is a truly formidable disease. What produces it imme-
diately or remotely we cannot tell. It may occur without the
least assignable cause in persons who have met with no accident,
and are otherwise in perfect health. Wasting palsy may affect
children and adults, male and female ; but it is suspected to
arise, sometimes, from protracted fatigue of certain muscles;
also from bruising, and from cold. It is almost always of slow
invasion, and is usually discovered first from the sensible loss of
power; for by this, the attention of the patient or friends is
drawn to the state of the muscles, when, perhaps, they are dis-
covered to be already wasted, or soft and degenerated. There
is also noticed, at times, a violent quivering in these muscles,
which does not cause motion of the limb, nor any kind of pain.
This quivering- does not attend all cases of this malady, but
when it does occur, it indicates that the disease is still advan-
cing, and if it ceases, the disease is arrested, or the muscles are
already totally destroyed. Some of these patients complain of
vibrating cramps that prevent their sleep, but such are quite
distinct from the tremblings. The muscle, or clan of muscles,
is progressively destroyed, while the nerve branches, even
down to the affected muscles, are at first apparently sound, and
the general nervous system appears to be quite healthy. The
attacked muscles appear, on dissection, of a pale yellow color,
are wasted as to number of fibres, and their bulk is often