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the sensitive nerves; while the opening of the up-running cur-
rent is felt merely in the motory, where the electric stream trav-
erses a mixed nerve. But we find that Dubois-Reymond, more
recently, does not sanction the terms idiopathic and symptomatic,
but says, " We do not yet possess any grounds on which to
establish the immediate excitement of the muscles to motion,
by means of the current, as we have no right to ascribe two
causes for one and the same effect, when one is quite sufficient
to account for it."
M. Nobili thereupon produced the results of his researches,
which can be considered as forming an epoch — a second start-
ing point — in the history of this department of physiology and
therapeutics. The greater part of his work, however, was also
directed to the laiv of convulsions, which was always thought by
those earlier writers as so important. But in the latter part of
his treatise we find the following conclusions, or rather doubtful
deductions; for he says, —
" By the rapidly repeated closure and opening of the circuit
that embraces a frog thigh, there appears a phenomenon which
bears the greatest resemblance to ordinary tetanus." Nobili
seems to suspect that in this idiopathic and traumatic disease,
the nerve fibrils are subjected to similarly rapid changes of ex-
citement and relaxation, that, taken together, produces the
tetanic spasms. He states that he has observed more than once,
that a frog which, from some unknown cause, had fallen into a
tetanus, has remained in that condition also during the working
of one direction of the current; but, by reversing the direction
of that current, the muscles relaxed. He alludes to this fact
for starting the query, whether the steady current working in
one certain direction, or perhaps in both directions in rapid suc-
cessions, may not possibly constitute the very specific means for
quieting the tetanus, or rather the means for preventing its de-
velopment ; but he does not seem to take into the account any
sort of reference to the cause of the tetanus; it must be as-
sumed that the cause of the tetanus is already removed. Let
us now, says Nobili, proceed from tetanus to paralysis, and ask,
what is the real condition obtained when we apply an electric