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ings of the different currents on the living organism in a
therapeutical point of view, and substantial truths will soon
accumulate; but we must first patiently investigate what has
already been done.
M. Marianini, in 1829, and Nobili, in 1834, were the first to
take up Volta's researches for thorough investigation. Maria-
nini at once declares himself at some difference from Volta's
views, because he supposed he found a difference in the opening-
convulsion ; i. e., the twitching that occurs on opening the cir-
cuit ; and this according to whether the current flows through
the muscle, or whether it flows through the nerve trunk. The
former he termed idiopathic, the latter symptomatic convul-
sions. In the first case, he thinks that each current direction,
and in the latter merely that one running opposite to the ner-
vous ramification, will admit of an opening convulsion. When
the current courses through the nerves in a direction contrary
to that of their ramifications, it will produce, instead of a con-
traction, a sensation; but when in the same direction as the
nervous ramification, i. e., down-running, it will cause the
contraction.
Such researches and results are all the more important and
interesting, because they were for the first time obtained, not
from the amputated frog legs, but from trials made on the live
frog, with the loins necessarily separated transversely, so that the
legs were connected with the body only by the large nerves.
Thus, when a current was directed upward through the nerve,
it produced at the opening of the chain a convulsion. If the
direction of the current was changed so as to run down, it occa-
sioned at the opening of the chain merely a cry from the frog;
but this did not invariably appear. As in those times, the the-
ory of C. Bell, or the microscopic structure of the nerves, were
not as yet known, it is no wonder M. Marianini did not more
fully see the prodigious bearing of these results of his own
researches, but which our present knowledge proves them to
deserve; namely, that the down-running current affects the
sensitive nerves more than it does the motory nerves ; and that
also the opening of the down-running circuit is felt merely in